Upgraded to safari 4.0.3 and now can't ...

I ran normal software upgrade and upgraded to Safari 4.0.3.
Now I can't open safari from the Dock or from the Applications folder - I get a "the application Safari Quit unexpectedly" message.

I have tried to 'reopen' but that makes no difference.
I have restarted machine several times.
I have run the disk utility to repair permssions and this makes no difference.

Below is the error report. Can anyone help please...

Date/Time: 2009-11-06 10:26:23.084 0000
OS Version: 10.4.11 (Build 8S165)
Report Version: 4

Command: Safari
Path: /Applications/Safari.app/Contents/MacOS/Safari
Parent: WindowServer 62

Version: 4.0.3 (4531.9)
Build Version: 1
Project Name: WebBrowser
Source Version: 45310900

PID: 205
Thread: 0

Exception: EXC_BAD_ACCESS (0x0001)
Codes: KERN_PROTECTION_FAILURE (0x0002) at 0x00000020

Thread 0 Crashed:
0

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